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SCP-193 Safe ~ medium confidence
SCP-193
Expected annual
$511K
One-time setup
$490K
Annual recurring
$499K
Personnel
2.7
One-time capital costs are moderate (~$0.49M) driven by HVAC isolation, analytic instrument choices, and specialized containment equipment; recurring annual costs are significant (~$0.50M/yr) driven primarily by personnel, research/analytic work, medical monitoring, disposal, and contingency reserves.
🏗️ One-Time Capital Costs Total: $490K
Initial Research And Lab Setup $150K
[#3, #16, #17] In-house analytic instrument capital (GC-MS / mass spec chosen as midpoint), initial research lab set-up for analytic workflows (optional larger instruments not purchased).
Equipment $117K
[#4, #5, #6, #14, #15, #18, #19, #24, #27] Incinerator or sealed containment purchase option, initial PAPR/SCBA and spill kits, autoclave, waste-air scrubber, -80C freezer, CCTV hardware, transport/transfer box, backup containment.
Emergency Response Reserve $100K
[#23] Dedicated one-time contingency/reserve seed for emergency response and remediation staging.
Facilities $85K
[#1, #2] Locker upgrade, negative-pressure/HVAC isolation installation, minor structural modifications.
Irb And Legal Setup $15K
[#12] One-time IRB/ethics setup and initial legal consultation for human-material handling.
Environmental Permitting $10K
[#26] One-time permitting fees for incinerator or emissions sources.
It Lims Setup $8K
[#21] One-time LIMS / secure data system setup and initial configuration.
Sop Development $5K
[#20] Development of written SOPs, emergency procedures, and initial documentation.
🔄 Annual Recurring Costs Total: $499K/yr
Staff Wages $220K/yr
[#7, #8] Salaries and benefits: 1research scientist + 1 full-time technician (and security overlay/consultant allocations).
Research And Monitoring $50K/yr
[#16, #17, #3] Annual research consumables, sequencing/proteomics service fees, microscopy/access fees and analytic run costs (outsourced work & reagents).
Long Term Care Reserve $50K/yr
[#10] Annual allocation toward long-term care / disability contingency pool for severe exposure outcomes.
Institutional Overhead $50K/yr
[#29] Institutional indirects / utilities allocation prorated to program scale.
Cover Story And Legal $30K/yr
[#12, #22] Ongoing legal retainer, PR/cover-up contingency and annual compliance/legal support.
Facilities Maintenance $24K/yr
[#2, #14, #18, #19, #15] HVAC filter replacement and negative-pressure monitoring, autoclave/freezer maintenance, CCTV/storage, scrubber/media replacement and routine equipment upkeep.
External Contract Research $20K/yr
[#28] Budget for periodic outsourced toxicology, animal models, or specialized chemical ID projects.
Mucus Procurement $15K/yr
[#11] Donor compensation, screening and cold-chain handling costs (weekly 30 cc feeds).
Supplies And Consumables $12K/yr
[#5, #13, #25, #15] PPE disposables and filters, routine sterile consumables, daily handling disposables, scrubber consumables.
Medical Monitoring $10K/yr
[#9] Baseline and periodic pulmonary exams, fit-testing, post-exposure diagnostics budget.
Logistics And Transport $5K/yr
[#24, #4] Per-move secure transport costs and occasional off-site transfer fees.
Training And Drills $5K/yr
[#6, #20] Recurring staff training, exercises, fit-testing, and SOP refresher drills.
Biohazard Disposal $5K/yr
[#4] Contracted medical/biohazard waste pickup (weekly) as ongoing operational cost.
It Hosting $3K/yr
[#21] LIMS/secure data hosting, backups and maintenance.
⚡ Cost Scenarios
📊 Baseline (baseline) $499K/yr
93.0% probability / year
Normal year with scheduled operations, routine research, and no major incidents.
routine handling and weekly feeding scheduled research and maintenance
🚨 Minor Incident $524K/yr
4.0% probability / year +$25K vs baseline
Small accidental exposure or containment lapse requiring medical follow-up, extra disposal, overtime and limited remediation.
accidental contact during handling PPE failure or transfer leak
🚨 Major Breach $999K/yr
1.0% probability / year +$500K vs baseline
Significant containment breach or exposure event leading to hospitalizations, environmental remediation, legal/PR response and replacement of equipment.
large-scale exposure / hospitalization incinerator/emissions incident or failed containment
🚨 Research Breakthrough Requiring Scale Up $799K/yr
2.0% probability / year +$300K vs baseline
Research identifies mechanisms requiring larger-scale experiments, new in-house instrumentation, and expanded staffing/facilities.
successful lead experiment decision to build in-house sequencing/analytical capacity
👥 Personnel 2.7 total
Role Count Notes
Research Scientist 1 Senior researcher responsible for molecular/physiological studies (~$120,000/yr included in staff_wages).
Lab Technician 1 Full-time technician for daily removal/incineration, feeding, monitoring (~$60,000/yr included in staff_wages).
Security Officer / MTF Agent (overlay) 0.5 Fractional security allocation for escorts/overlay and containment checks (~$20,000/yr allocated).
Consultant (toxicologist / gas chemist) 0.2 Part-time external consultant allocation (~$20,000/yr included in staff_wages/external_contract_research).
📋 Confidence Notes
Many line items have wide ranges (especially instrumentation, incinerator vs contract disposal, and liability reserves). Staff and consumable estimates are better-constrained; overall program cost is moderately certain but could vary substantially depending on in-house instrument choices and contingency events.
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